A hypoxia efficient imidazole-based Ru(II) arene anticancer agent resistant to deactivation by glutathione.
نویسندگان
چکیده
A slow hydrolyzing imidazole-based Ru(II)-arene complex [(L)Ru(II)(η(6)-p-cym)(Cl)](PF6) (1) with excellent stability in the extracellular chloride concentration shows better activity under hypoxia and strong resistance to glutathione (GSH) in vitro under hypoxic conditions. 1 arrests the cell cycle in sub G1 and G2/M phases and leads to apoptosis.
منابع مشابه
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ورودعنوان ژورنال:
- Dalton transactions
دوره 44 13 شماره
صفحات -
تاریخ انتشار 2015